In silico modeling of oxygen-enhanced MRI of specific ventilation
نویسندگان
چکیده
منابع مشابه
Vertical distribution of specific ventilation in normal supine humans measured by oxygen-enhanced proton MRI.
Specific ventilation (SV) is the ratio of fresh gas entering a lung region divided by its end-expiratory volume. To quantify the vertical (gravitationally dependent) gradient of SV in eight healthy supine subjects, we implemented a novel proton magnetic resonance imaging (MRI) method. Oxygen is used as a contrast agent, which in solution changes the longitudinal relaxation time (T1) in lung tis...
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PURPOSE To assess the viability of oxygen-enhanced ventilation images using ultra-short echo time magnetic resonance imaging (UTE-MRI). METHODS We evaluated the oxygen enhancement of the pulmonary T2*, and pulmonary signals in each TE (0.2, 0.8, 1.4, 2.0 ms) in 21 nonsmokers. RESULTS The oxygen enhancement of pulmonary signals was the most significant (32%) at the 0.2 ms TE, the second in t...
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PURPOSE: Oxygen Enhanced MRI with 3D radial ultrashort echo time (OE-MRI) is an emerging technique for the evaluation of lung ventilation. Contrast corresponding to ventilation may be achieved in patients due to the paramagnetic T1 shortening effect of breathing different concentrations of O2. OE-MRI holds potential for rapid clinical translation due to the cost effectiveness and simple imaging...
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P. L. Hubbard, G. J. Parker, D. Singh, J. Vestbo, S. S. Young, E. Bondesson, L. E. Olsson, and J. H. Naish Imaging Sciences and Biomedical Engineering, University of Manchester, Manchester, United Kingdom, The University of Manchester Biomedical Imaging Institute, Manchester, United Kingdom, Airway Pharmacology Group, School of Translational Medicine, University Hospital of South Manchester Fou...
متن کاملOxygen-enhanced MRI of the Lung
Highlights • Molecular oxygen is paramagnetic and lowers the T1 of nearby protons • Altering the concentration of inhaled O2 changes lung T1-weighted signal • Potential tool for assessing lung function with widespread availability • While usually considered a measure of regional lung ventilation, likely also a function of regional perfusion • Emerging methods address inherently low SNR and impr...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2018
ISSN: 2051-817X
DOI: 10.14814/phy2.13659